The course will illustrate how the structural and functional features of metalloproteins and metalloenzymes were deciphered using few chemical principles. More, during the course it will be described how the same chemical principles were used to design new active sites into proteins.

Along with examples form the literature and from the real Nature’s world, during the course the Protein Data Bank, the software PyMol (proteins and nucleic acids analysis and visualization) and the software FoldIt (protein modelization) will be presented by means of practical lectures in the computer’s room.